Anthracycline-based chemotherapy is a common treatment for cancer patients.Because it is delivered intravenously, endothelial cells are exposed first and to the highest concentrations, prior to diffusion to target cells.Not surprisingly, vascular dysfunction is a consequence of anthracycline therapy.While chemotherapy-induced endothelial damage at
Mechanics has been a central focus of physical biology in the past decade.In comparison, how cells manage their size is less understood.Here, we show that a parameter central to both the physics and the physiology of the cell, its volume, depends on a mechano-osmotic coupling.We found that cells change their volume depending on the rate at which th
Dynamic knee valgus (DKV) occurs during landing after a fatigue task involving the lower extremity.However, the manner in which different peripheral fatigue tasks affect DKV remains unknown.In this study, we investigated the DKV via electromyography during single-leg landing considering the hip-joint fatigue task (HFT) and knee-joint fatigue task (